Assay Detail
Functional
CHEMBL1024704
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Agonist activity at rat mu opioid receptor expressed in mouse HN9.10 cells by [35S]GTPgammaS binding assay
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.69 | 8.15 |
| pEC50 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507340 | — | — | 2 | 8.15 |
| CHEMBL448998 | — | — | 2 | 7.68 |
| CHEMBL389652 | — | — | 2 | 7.50 |
| CHEMBL38874 | DAMGO | — | 2 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507340 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL448998 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL389652 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL38874 | DAMGO | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL389652 | — | pEC50 | = | 7.5 | nM | - |
| CHEMBL38874 | DAMGO | pEC50 | = | 7.4 | nM | - |
| CHEMBL448998 | — | pEC50 | = | 7.7 | nM | - |
| CHEMBL507340 | — | pEC50 | = | 8.2 | nM | - |