Assay Detail
Functional
CHEMBL1025452
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Inhibition of chemotaxis in human neutrophils assessed as inhibition of IL8-induced migration by Boyden chamber assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.59 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511751 | — | — | 1 | 10.70 |
| CHEMBL468124 | — | — | 1 | 10.00 |
| CHEMBL467923 | — | — | 1 | 9.74 |
| CHEMBL467928 | — | — | 1 | 9.68 |
| CHEMBL480667 | — | — | 1 | 9.31 |
| CHEMBL519957 | — | — | 1 | 9.21 |
| CHEMBL466220 | — | — | 1 | 8.87 |
| CHEMBL480666 | — | — | 1 | 8.79 |
| CHEMBL511750 | — | — | 1 | 8.48 |
| CHEMBL466489 | — | — | 1 | 8.41 |
| CHEMBL512810 | — | — | 1 | 8.16 |
| CHEMBL482244 | — | — | 1 | 7.97 |
| CHEMBL512642 | — | — | 1 | 7.83 |
| CHEMBL466219 | — | — | 1 | 7.53 |
| CHEMBL468724 | — | — | 1 | 7.51 |
| CHEMBL466490 | — | — | 1 | 7.07 |
| CHEMBL513296 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511751 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL468124 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL467923 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL467928 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL480667 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL519957 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL466220 | — | IC50 | = | 1.36 | nM | 8.87 |
| CHEMBL480666 | — | IC50 | = | 1.61 | nM | 8.79 |
| CHEMBL511750 | — | IC50 | = | 3.32 | nM | 8.48 |
| CHEMBL466489 | — | IC50 | = | 3.89 | nM | 8.41 |
| CHEMBL512810 | — | IC50 | = | 6.86 | nM | 8.16 |
| CHEMBL482244 | — | IC50 | = | 10.79 | nM | 7.97 |
| CHEMBL512642 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL466219 | — | IC50 | = | 29.64 | nM | 7.53 |
| CHEMBL468724 | — | IC50 | = | 31.22 | nM | 7.51 |
| CHEMBL466490 | — | IC50 | = | 85.44 | nM | 7.07 |
| CHEMBL513296 | — | IC50 | = | 171.63 | nM | 6.76 |