Assay Detail
Binding
CHEMBL1025517
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Inhibition of CSF1R
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.82 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481423 | — | — | 1 | 8.70 |
| CHEMBL481223 | — | — | 1 | 8.52 |
| CHEMBL481401 | — | — | 1 | 8.52 |
| CHEMBL480445 | — | — | 1 | 8.22 |
| CHEMBL481806 | — | — | 1 | 8.22 |
| CHEMBL480457 | — | — | 1 | 8.10 |
| CHEMBL480618 | — | — | 1 | 7.96 |
| CHEMBL480617 | — | — | 1 | 7.64 |
| CHEMBL519924 | — | — | 1 | 7.62 |
| CHEMBL479847 | — | — | 1 | 7.60 |
| CHEMBL481596 | — | — | 1 | 7.27 |
| CHEMBL480456 | — | — | 1 | 7.23 |
| CHEMBL481400 | — | — | 1 | 6.96 |
| CHEMBL521407 | — | — | 1 | 6.89 |
| CHEMBL481008 | — | — | 1 | - |
| CHEMBL480250 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481423 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL481223 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL481401 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL480445 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL481806 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL480457 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL480618 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL480617 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL519924 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL479847 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL481596 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL480456 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL481400 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL521407 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL481008 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL480250 | — | IC50 | < | 3.0 | nM | - |