Assay Detail
Binding
CHEMBL1025549
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Inhibition of PCAF HAT domain (493-658) expressed in Escherichia coli BL21 (DE3)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Bisubstrate Inhibitors of the MYST HATs Esa1 and Tip60.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.49 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526343 | — | — | 1 | 5.64 |
| CHEMBL1213327 | COENZYME_A | 3.0 | 1 | 4.38 |
| CHEMBL500256 | — | — | 1 | 4.27 |
| CHEMBL504265 | — | — | 1 | 4.23 |
| CHEMBL509144 | — | — | 1 | 4.22 |
| CHEMBL505605 | — | — | 1 | 4.18 |
| CHEMBL448227 | — | — | 1 | - |
| CHEMBL505121 | — | — | 1 | - |
| CHEMBL455368 | ANACARDIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526343 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL1213327 | COENZYME_A | IC50 | = | 41910.0 | nM | 4.38 |
| CHEMBL500256 | — | IC50 | = | 53570.0 | nM | 4.27 |
| CHEMBL504265 | — | IC50 | = | 58470.0 | nM | 4.23 |
| CHEMBL509144 | — | IC50 | = | 60540.0 | nM | 4.22 |
| CHEMBL505605 | — | IC50 | = | 65930.0 | nM | 4.18 |
| CHEMBL448227 | — | IC50 | = | 124300.0 | nM | - |
| CHEMBL505121 | — | IC50 | = | 108300.0 | nM | - |
| CHEMBL455368 | ANACARDIC ACID | IC50 | = | 667050.0 | nM | - |