Assay Detail
Functional
CHEMBL1025564
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Antiviral activity against multidrug-resistant HIV1 with protease V82A, M46I, F53L, V77I, L24I, L63P mutation in human SupT1 cells assessed as viral LTR-driven luciferase activity using TZM-bl cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | SUP-T1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.58 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503571 | — | — | 1 | 6.58 |
| CHEMBL449611 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503571 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL449611 | — | EC50 | > | 1000000.0 | nM | - |