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Assay Detail

CHEMBL1025580

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV2 ROD in human CEM cells
16
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 2
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 2 (CHEMBL380)
Type ORGANISM
Organism Human immunodeficiency virus 2

Publication

Intracellular trapping of cycloSal-pronucleotides: modification of prodrugs with amino acid esters.
Jessen HJ, Balzarini J, Meier C.
J Med Chem (2008) 51 : 6592 -6598
PubMed 18826203 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 6.28 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL375767 1 6.89
CHEMBL509558 3 6.52
CHEMBL490178 1 6.48
CHEMBL523323 1 6.40
CHEMBL486885 1 6.40
CHEMBL483856 1 6.40
CHEMBL510489 1 6.33
CHEMBL374450 1 6.28
CHEMBL991 STAVUDINE 4.0 1 6.20
CHEMBL519856 1 6.16
CHEMBL490399 1 6.10
CHEMBL491197 1 5.96
CHEMBL483654 1 5.80
CHEMBL519567 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL375767 EC50 = 130.0 nM 6.89
CHEMBL509558 EC50 = 300.0 nM 6.52
CHEMBL490178 EC50 = 330.0 nM 6.48
CHEMBL523323 EC50 = 400.0 nM 6.40
CHEMBL509558 EC50 = 400.0 nM 6.40
CHEMBL509558 EC50 = 400.0 nM 6.40
CHEMBL486885 EC50 = 400.0 nM 6.40
CHEMBL483856 EC50 = 400.0 nM 6.40
CHEMBL510489 EC50 = 470.0 nM 6.33
CHEMBL374450 EC50 = 530.0 nM 6.28
CHEMBL991 STAVUDINE EC50 = 630.0 nM 6.20
CHEMBL519856 EC50 = 700.0 nM 6.16
CHEMBL490399 EC50 = 800.0 nM 6.10
CHEMBL491197 EC50 = 1100.0 nM 5.96
CHEMBL483654 EC50 = 1600.0 nM 5.80
CHEMBL519567 EC50 = 1600.0 nM 5.80