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Assay Detail

CHEMBL1025641

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Binding
Inhibition of Bacillus stearothermophilus alpha-glucosidase
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Geobacillus stearothermophilus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Chlorogenic acid derivatives with alkyl chains of different lengths and orientations: potent alpha-glucosidase inhibitors.
Ma CM, Hattori M, Daneshtalab M, Wang L.
J Med Chem (2008) 51 : 6188 -6194
PubMed 18783210 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.48 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL404271 ACARBOSE 4.0 1 7.00
CHEMBL509517 1 6.16
CHEMBL506425 1 6.10
CHEMBL499714 1 6.10
CHEMBL502397 1 6.10
CHEMBL503916 1 6.05
CHEMBL505662 1 6.05
CHEMBL506364 1 5.96
CHEMBL446766 1 5.75
CHEMBL444178 1 5.70
CHEMBL460785 DUVOGLUSTAT HYDROCHLORIDE 2.0 1 5.62
CHEMBL468461 1 5.44
CHEMBL460559 1 5.41
CHEMBL448076 1 5.29
CHEMBL511429 1 5.26
CHEMBL461200 1 4.96
CHEMBL462263 1 4.90
CHEMBL460345 1 4.85
CHEMBL462248 1 4.84
CHEMBL462264 1 4.53
CHEMBL462047 1 4.35
CHEMBL516984 1 4.21
CHEMBL284616 CHLOROGENIC ACID 2.0 1 -
CHEMBL459498 1 -
CHEMBL518663 1 -
CHEMBL462039 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL404271 ACARBOSE IC50 = 100.0 nM 7.00
CHEMBL509517 IC50 = 700.0 nM 6.16
CHEMBL506425 IC50 = 800.0 nM 6.10
CHEMBL499714 IC50 = 800.0 nM 6.10
CHEMBL502397 IC50 = 800.0 nM 6.10
CHEMBL503916 IC50 = 900.0 nM 6.05
CHEMBL505662 IC50 = 900.0 nM 6.05
CHEMBL506364 IC50 = 1100.0 nM 5.96
CHEMBL446766 IC50 = 1800.0 nM 5.75
CHEMBL444178 IC50 = 2000.0 nM 5.70
CHEMBL460785 DUVOGLUSTAT HYDROCHLORIDE IC50 = 2400.0 nM 5.62
CHEMBL468461 IC50 = 3600.0 nM 5.44
CHEMBL460559 IC50 = 3900.0 nM 5.41
CHEMBL448076 IC50 = 5100.0 nM 5.29
CHEMBL511429 IC50 = 5500.0 nM 5.26
CHEMBL461200 IC50 = 10900.0 nM 4.96
CHEMBL462263 IC50 = 12500.0 nM 4.90
CHEMBL460345 IC50 = 14200.0 nM 4.85
CHEMBL462248 IC50 = 14400.0 nM 4.84
CHEMBL462264 IC50 = 29600.0 nM 4.53
CHEMBL462047 IC50 = 44900.0 nM 4.35
CHEMBL516984 IC50 = 62200.0 nM 4.21
CHEMBL284616 CHLOROGENIC ACID IC50 = 2822500.0 nM -
CHEMBL459498 IC50 = 154200.0 nM -
CHEMBL518663 IC50 = 127800.0 nM -
CHEMBL462039 IC50 = 2536100.0 nM -