Assay Detail
Functional
CHEMBL1025675
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Inhibition of TNF-alpha-induced IL8 production in human whole blood cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.54 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494272 | — | — | 1 | 9.05 |
| CHEMBL494469 | — | — | 1 | 8.92 |
| CHEMBL493670 | — | — | 1 | 8.80 |
| CHEMBL492265 | — | — | 1 | 8.60 |
| CHEMBL493671 | — | — | 1 | 8.57 |
| CHEMBL495330 | — | — | 1 | 8.46 |
| CHEMBL494270 | — | — | 1 | 8.37 |
| CHEMBL493708 | — | — | 1 | 8.09 |
| CHEMBL494072 | — | — | 1 | 7.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494272 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL494469 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL493670 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL492265 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL493671 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL495330 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL494270 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL493708 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL494072 | — | IC50 | = | 10.7 | nM | 7.97 |