Assay Detail
Functional
CHEMBL1026071
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Antiproliferative activity against human A375 cells after 72 to 144 hrs by cyquant DNA dye method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.22 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL563608 | — | — | 1 | 8.05 |
| CHEMBL560895 | SNX-2112 | -1.0 | 1 | 7.64 |
| CHEMBL553939 | — | — | 1 | 7.29 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL563608 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL560895 | SNX-2112 | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL553939 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1287.0 | nM | 5.89 |