Assay Detail
Functional
CHEMBL1026201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of melanin synthesis in NHEM after 24 hrs by liquid scintillation
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Melanin synthesis inhibitors from Lespedeza cyrtobotrya.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 5.31 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL563180 | LESPECYRTIN E3 | — | 1 | 6.40 |
| CHEMBL494083 | XANTHOANGELOL | — | 1 | 6.01 |
| CHEMBL559972 | LESPECYRTIN B2 | — | 1 | 6.00 |
| CHEMBL561912 | LESPECYRTIN B1 | — | 1 | 5.89 |
| CHEMBL253467 | ISOBAVACHALCONE | — | 1 | 5.85 |
| CHEMBL560771 | LESPECYRTIN E5 | — | 1 | 5.82 |
| CHEMBL558103 | ABYSSINONE II | — | 1 | 5.70 |
| CHEMBL564141 | ERYBRAEDIN A | — | 1 | 5.70 |
| CHEMBL185018 | — | — | 1 | 5.70 |
| CHEMBL554280 | LESPECYRTIN D1 | — | 1 | 5.68 |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | 5.66 |
| CHEMBL560422 | LESPEOL | — | 1 | 5.62 |
| CHEMBL549416 | LESPECYRTIN C1 | — | 1 | 5.52 |
| CHEMBL229885 | LICOAGROCHALCONE A | — | 1 | 5.50 |
| CHEMBL562032 | LESPEFLORIN G4 | — | 1 | 5.50 |
| CHEMBL560646 | LESPECYRTIN E6 | — | 1 | 5.47 |
| CHEMBL551303 | LESPECYRTIN E2 | — | 1 | 5.43 |
| CHEMBL557492 | LESPECYRTIN E4 | — | 1 | 5.35 |
| CHEMBL556468 | GANGETININ | — | 1 | 5.34 |
| CHEMBL549617 | UNCINANONE A | — | 1 | 5.27 |
| CHEMBL455372 | ERYBRAEDIN C | — | 1 | 5.26 |
| CHEMBL538959 | LESPECYRTIN H4 | — | 1 | 5.21 |
| CHEMBL448350 | PHASEOLIN | — | 1 | 5.12 |
| CHEMBL508534 | PHASEOLLIDIN | — | 1 | 5.06 |
| CHEMBL559191 | LESPECYRTIN H1 | — | 1 | 5.05 |
| CHEMBL541224 | LESPECYRTIN B3 | — | 1 | 5.04 |
| CHEMBL512693 | NEOBAVAISOFLAVONE | — | 1 | 5.03 |
| CHEMBL539455 | LESPECYRTIN H3 | — | 1 | 5.00 |
| CHEMBL252642 | LIQUIRTIGENIN | — | 1 | 4.83 |
| CHEMBL551908 | LESPECYRTIN F2 | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL563180 | LESPECYRTIN E3 | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL494083 | XANTHOANGELOL | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL559972 | LESPECYRTIN B2 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL561912 | LESPECYRTIN B1 | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL253467 | ISOBAVACHALCONE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL560771 | LESPECYRTIN E5 | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL558103 | ABYSSINONE II | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL564141 | ERYBRAEDIN A | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL185018 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL554280 | LESPECYRTIN D1 | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL232202 | ARBUTIN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL560422 | LESPEOL | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL549416 | LESPECYRTIN C1 | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL229885 | LICOAGROCHALCONE A | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL562032 | LESPEFLORIN G4 | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL560646 | LESPECYRTIN E6 | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL551303 | LESPECYRTIN E2 | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL557492 | LESPECYRTIN E4 | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL556468 | GANGETININ | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL549617 | UNCINANONE A | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL455372 | ERYBRAEDIN C | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL538959 | LESPECYRTIN H4 | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL448350 | PHASEOLIN | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL508534 | PHASEOLLIDIN | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL559191 | LESPECYRTIN H1 | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL541224 | LESPECYRTIN B3 | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL512693 | NEOBAVAISOFLAVONE | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL539455 | LESPECYRTIN H3 | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL252642 | LIQUIRTIGENIN | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL551908 | LESPECYRTIN F2 | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL550232 | LESPECYRTIN E7 | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL469444 | BAVACHIN | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL564881 | LESPEFLORIN I2 | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL44 | GENISTEIN | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL556942 | BAVAISOFLAVANONE | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL9352 | NARINGENIN | IC50 | = | 73500.0 | nM | 4.13 |
| CHEMBL564769 | — | IC50 | - | — | - | |
| CHEMBL537 | HYDROQUINONE | IC50 | = | 103000.0 | nM | - |
| CHEMBL551764 | LESPECYRTIN F1 | IC50 | - | — | - | |
| CHEMBL564378 | LESPECYRTIN G1 | IC50 | - | — | - | |
| CHEMBL561048 | — | IC50 | - | — | - | |
| CHEMBL516930 | LEACHIANONE G | IC50 | - | — | - | |
| CHEMBL556682 | LESPECYRTIN A1 | IC50 | - | — | - | |
| CHEMBL491534 | ISOBAVACHIN | IC50 | - | — | - | |
| CHEMBL538958 | LESPECYRTIN H2 | IC50 | - | — | - |