Assay Detail
Functional
CHEMBL1026412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 LAI in human MT2 cells assessed as inhibition of virus-induced cytopathic effect
17
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.93 | 8.47 |
| ID50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523528 | — | — | 1 | 8.47 |
| CHEMBL492254 | — | — | 1 | 8.31 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.80 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.57 |
| CHEMBL517126 | — | — | 1 | 7.52 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 2 | - |
| CHEMBL510485 | — | — | 1 | - |
| CHEMBL494114 | — | — | 1 | - |
| CHEMBL492666 | — | — | 1 | - |
| CHEMBL494500 | — | — | 1 | - |
| CHEMBL494499 | — | — | 1 | - |
| CHEMBL512807 | — | — | 1 | - |
| CHEMBL450294 | — | — | 1 | - |
| CHEMBL449291 | — | — | 1 | - |
| CHEMBL503401 | — | — | 1 | - |
| CHEMBL469086 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523528 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL492254 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL517126 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL510485 | — | IC50 | - | — | - | |
| CHEMBL494114 | — | IC50 | - | — | - | |
| CHEMBL492666 | — | IC50 | - | — | - | |
| CHEMBL494500 | — | IC50 | - | — | - | |
| CHEMBL494499 | — | IC50 | - | — | - | |
| CHEMBL512807 | — | IC50 | - | — | - | |
| CHEMBL450294 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL449291 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL503401 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1323 | DARUNAVIR | ID50 | = | 1.6 | nM | - |
| CHEMBL1323 | DARUNAVIR | IC50 | - | — | - | |
| CHEMBL469086 | — | ID50 | = | 1.2 | nM | - |