Assay Detail

CHEMBL1027063

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Functional

Antiviral activity against HIV1 BaL in peripheral blood lymphocytes

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Safety and pharmacokinetics of GSK364735, a human immunodeficiency virus type 1 integrase inhibitor, following single and repeated administration in healthy adult subjects.

Reddy YS, Min SS, Borland J, Song I, Lin J, Palleja S, Symonds WT.
Antimicrob Agents Chemother (2007) 51 : 4284 -4289
PubMed 17923489 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.92	8.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1256978	GSK-364735	2.0	1	8.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1256978	GSK-364735	IC50	=	1.2	nM	8.92