Assay Detail
Functional
CHEMBL1027224
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Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.09 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.14 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.51 |
| CHEMBL182739 | — | — | 1 | 8.15 |
| CHEMBL444562 | — | — | 1 | 7.62 |
| CHEMBL444693 | — | — | 1 | 7.17 |
| CHEMBL482340 | — | — | 1 | 7.12 |
| CHEMBL473857 | — | — | 1 | 7.12 |
| CHEMBL474864 | — | — | 1 | 7.07 |
| CHEMBL506441 | — | — | 1 | 7.07 |
| CHEMBL514635 | — | — | 1 | 6.88 |
| CHEMBL474256 | — | — | 1 | 6.88 |
| CHEMBL519303 | — | — | 1 | 6.80 |
| CHEMBL499940 | — | — | 1 | 6.72 |
| CHEMBL475873 | — | — | 1 | 6.70 |
| CHEMBL454710 | — | — | 1 | 6.69 |
| CHEMBL502039 | — | — | 1 | 6.50 |
| CHEMBL475874 | — | — | 1 | 6.27 |
| CHEMBL502241 | — | — | 1 | 6.12 |
| CHEMBL321473 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL182739 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL444562 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL444693 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL482340 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL473857 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL474864 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL506441 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL514635 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL474256 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL519303 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL499940 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL475873 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL454710 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL502039 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL475874 | — | IC50 | = | 541.0 | nM | 6.27 |
| CHEMBL502241 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL321473 | — | IC50 | = | 753.0 | nM | 6.12 |