Assay Detail
Functional
CHEMBL1027329
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Phototoxicity against human HCT116 cells after 24 hrs irradiated with tungsten-halogen white light for 2 hrs followed by incubation in drug free medium for 24 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Photodynamic effects of novel 5,15-diaryl-tetrapyrrole derivatives on human colon carcinoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.39 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210258 | — | — | 1 | 8.97 |
| CHEMBL207155 | — | — | 1 | 8.25 |
| CHEMBL210267 | — | — | 1 | 8.23 |
| CHEMBL500576 | TEMOPORFIN | 4.0 | 1 | 8.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210258 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL207155 | — | IC50 | = | 5.66 | nM | 8.25 |
| CHEMBL210267 | — | IC50 | = | 5.94 | nM | 8.23 |
| CHEMBL500576 | TEMOPORFIN | IC50 | = | 7.6 | nM | 8.12 |