Assay Detail
Binding
CHEMBL1027336
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Inhibition of ACAT in human HepG2 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.13 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL454397 | — | — | 1 | 7.51 |
| CHEMBL449832 | — | — | 1 | 7.50 |
| CHEMBL453491 | — | — | 1 | 7.50 |
| CHEMBL459999 | — | — | 1 | 7.46 |
| CHEMBL500498 | — | — | 1 | 7.43 |
| CHEMBL449977 | — | — | 1 | 7.40 |
| CHEMBL501429 | — | — | 1 | 7.37 |
| CHEMBL510453 | — | — | 1 | 7.33 |
| CHEMBL442567 | — | — | 1 | 7.32 |
| CHEMBL503766 | — | — | 1 | 7.32 |
| CHEMBL447674 | — | — | 1 | 7.31 |
| CHEMBL509834 | — | — | 1 | 7.17 |
| CHEMBL443151 | — | — | 1 | 7.11 |
| CHEMBL448407 | — | — | 1 | 7.09 |
| CHEMBL499122 | — | — | 1 | 7.09 |
| CHEMBL364823 | — | — | 1 | 6.85 |
| CHEMBL101309 | AVASIMIBE | 2.0 | 1 | 6.32 |
| CHEMBL459998 | — | — | 1 | 6.26 |
| CHEMBL459791 | — | — | 1 | 6.18 |
| CHEMBL517393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL454397 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL449832 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL453491 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL459999 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL500498 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL449977 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL501429 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL510453 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL442567 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL503766 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL447674 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL509834 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL443151 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL448407 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL499122 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL364823 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL101309 | AVASIMIBE | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL459998 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL459791 | — | IC50 | = | 664.0 | nM | 6.18 |
| CHEMBL517393 | — | IC50 | > | 1000.0 | nM | - |