Assay Detail
Binding
CHEMBL1027395
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MK2 expressed in Escherichia coli BL21(DE3) after 60 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-activated protein kinase 2 (CHEMBL2208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.48 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226403 | — | — | 1 | 8.07 |
| CHEMBL510545 | — | — | 1 | 7.31 |
| CHEMBL57481 | — | — | 1 | 4.07 |
| CHEMBL122617 | 1-NAPHTHOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226403 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL510545 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL57481 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL122617 | 1-NAPHTHOL | IC50 | > | 100000.0 | nM | - |