Compound Detail
CHEMBL122617
1-NAPHTHOL Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL122617 |
| Name | 1-NAPHTHOL |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KJCVRFUGPWSIIH-UHFFFAOYSA-N |
4
Targets
11
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
144.2
MW (Da)
2.55
ALogP
1
HBA
1
HBD
20.2
PSA (Ų)
0.60
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 11 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclooxygenase CHEMBL2096674 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Cytochrome P450 1A2 CHEMBL3356 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL312 | IC50 | 5.44 | 5.44 | 3600.0 | 2 |
| Plasmodium falciparum CHEMBL364 | IC50 | 4.25 | 4.25 | 56510.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclooxygenase | IC50 | = | 2000.0 | nM | 5.7 | In vitro inhibition of Prostaglandin G/H synthase in BSV cell line. | 2104936 |
| Cytochrome P450 1A2 | IC50 | = | 3200.0 | nM | 5.5 | Inhibitory concentration against recombinant human cytochrome P450 1A2 | 15916432 |
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 3600.0 | nM | 5.44 | Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic ... | 2104936 |
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 3600.0 | nM | 5.44 | Inhibition of 5-lipoxygenase in Rattus norvegicus Rat basophil leukemia cells (R... | - |
| Plasmodium falciparum | IC50 | = | 56510.0 | nM | 4.25 | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 ... | 22196513 |
Literature References
Data from ChEMBL 36 via Core Engine