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Assay Detail

CHEMBL767495

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of Prostaglandin G/H synthase in BSV cell line.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type BSV
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Cyclooxygenase (CHEMBL2096674)
Type PROTEIN FAMILY
Organism Bos taurus

Publication

2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.
Batt DG, Maynard GD, Petraitis JJ, Shaw JE, Galbraith W, Harris RR.
J Med Chem (1990) 33 : 360 -370
PubMed 2104936 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.97 5.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6 INDOMETHACIN 4.0 1 5.75
CHEMBL122617 1-NAPHTHOL 1 5.70
CHEMBL122962 1 5.57
CHEMBL122451 1 5.52
CHEMBL85000 1 5.47
CHEMBL122258 1 5.23
CHEMBL122986 1 5.06
CHEMBL122544 1 4.96
CHEMBL122809 1 4.89
CHEMBL332663 1 4.89
CHEMBL52 NORDIHYDROGUAIARETIC ACID 1 4.85
CHEMBL122078 1 4.80
CHEMBL123054 1 4.75
CHEMBL436193 1 4.75
CHEMBL544593 1 4.75
CHEMBL122335 1 4.46
CHEMBL122254 1 4.43
CHEMBL331629 1 4.28
CHEMBL172049 1 4.24
CHEMBL340782 1 -
CHEMBL123179 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6 INDOMETHACIN IC50 = 1800.0 nM 5.75
CHEMBL122617 1-NAPHTHOL IC50 = 2000.0 nM 5.70
CHEMBL122962 IC50 = 2700.0 nM 5.57
CHEMBL122451 IC50 = 3000.0 nM 5.52
CHEMBL85000 IC50 = 3400.0 nM 5.47
CHEMBL122258 IC50 = 5900.0 nM 5.23
CHEMBL122986 IC50 = 8700.0 nM 5.06
CHEMBL122544 IC50 = 11000.0 nM 4.96
CHEMBL122809 IC50 = 13000.0 nM 4.89
CHEMBL332663 IC50 = 13000.0 nM 4.89
CHEMBL52 NORDIHYDROGUAIARETIC ACID IC50 = 14000.0 nM 4.85
CHEMBL122078 IC50 = 16000.0 nM 4.80
CHEMBL123054 IC50 = 18000.0 nM 4.75
CHEMBL436193 IC50 = 18000.0 nM 4.75
CHEMBL544593 IC50 = 18000.0 nM 4.75
CHEMBL122335 IC50 = 35000.0 nM 4.46
CHEMBL122254 IC50 = 37000.0 nM 4.43
CHEMBL331629 IC50 = 52000.0 nM 4.28
CHEMBL172049 IC50 = 57000.0 nM 4.24
CHEMBL340782 IC50 = 240000.0 nM -
CHEMBL123179 IC50 = 720000.0 nM -