Cyclooxygenase · PROTEIN FAMILY · Bos taurus
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As of 2026-09-13Protein identity stays anchored to UniProt O62664. Use UniProt O62664 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O62664 as the stable identity anchor, then attach disease evidence before program review.
Prostaglandin G/H synthase 1
Review this target as Cyclooxygenase, mapped to UniProt O62664. ChEMBL maps the protein component as Prostaglandin G/H synthase 1. Sequence length is 600 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cyclooxygenase as ChEMBL target CHEMBL2096674, mapped to UniProt O62664. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cyclooxygenase |
| Target Type | PROTEIN FAMILY |
| Organism | Bos taurus |
| UniProt | O62664 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prostaglandin G/H synthase 1 |
| UniProt Accession | O62664 |
| Component Type | Protein |
| Sequence Length | 600 aa |
Prostaglandin G/H synthase 1
Review this target as Cyclooxygenase, mapped to UniProt O62664. ChEMBL maps the protein component as Prostaglandin G/H synthase 1. Sequence length is 600 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL432463 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL6 | 7.96 | IC50 | 11.0 | Approved |
| CHEMBL28976 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL28507 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL28508 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL281012 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL292239 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL29047 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL538408 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL418035 | 7.3 | IC50 | 50.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 12 | 85 | 6.0 |
| tissue-based format | 5 | 38 | 5.7 |
| organism-based format | 4 | 10 | 5.3 |
| microsome format | 3 | 1 | 6.0 |
| assay format | 1 | 0 | — |
| cell-based format | 1 | 21 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 7.9 |
| microsome format | 1 | 0 | — |