Assay Detail
Binding
CHEMBL3074514
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-lipoxygenase in Rattus norvegicus Rat basophil leukemia cells (RBL) cells
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Molecular modeling and pharmacophore approach for structural requirements of some 2-substituted-1-naphthols derivatives as potent 5-lipoxygenase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 6.69 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436193 | — | — | 1 | 7.96 |
| CHEMBL85000 | — | — | 1 | 7.72 |
| CHEMBL123219 | — | — | 1 | 7.70 |
| CHEMBL122929 | — | — | 1 | 7.62 |
| CHEMBL331447 | — | — | 1 | 7.51 |
| CHEMBL421079 | — | — | 1 | 7.43 |
| CHEMBL331494 | — | — | 1 | 7.41 |
| CHEMBL341270 | — | — | 1 | 7.40 |
| CHEMBL122544 | — | — | 1 | 7.35 |
| CHEMBL124601 | — | — | 1 | 7.32 |
| CHEMBL124176 | — | — | 1 | 7.32 |
| CHEMBL122930 | — | — | 1 | 7.29 |
| CHEMBL123135 | — | — | 1 | 7.28 |
| CHEMBL414425 | — | — | 1 | 7.27 |
| CHEMBL332437 | — | — | 1 | 7.25 |
| CHEMBL123054 | — | — | 1 | 7.25 |
| CHEMBL122809 | — | — | 1 | 7.24 |
| CHEMBL421278 | — | — | 1 | 7.24 |
| CHEMBL123317 | — | — | 1 | 7.24 |
| CHEMBL333044 | — | — | 1 | 7.22 |
| CHEMBL126213 | — | — | 1 | 7.21 |
| CHEMBL123283 | — | — | 1 | 7.21 |
| CHEMBL123134 | — | — | 1 | 7.17 |
| CHEMBL122986 | — | — | 1 | 7.16 |
| CHEMBL339908 | — | — | 1 | 7.14 |
| CHEMBL331310 | — | — | 1 | 7.12 |
| CHEMBL123819 | — | — | 1 | 7.11 |
| CHEMBL333111 | — | — | 1 | 7.08 |
| CHEMBL333260 | — | — | 1 | 7.06 |
| CHEMBL331305 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436193 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL85000 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL123219 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL122929 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL331447 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL421079 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL331494 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL341270 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL122544 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL124601 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL124176 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL122930 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL123135 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL414425 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL123054 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL332437 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL122809 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL421278 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL123317 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL333044 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL126213 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL123283 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL123134 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL122986 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL339908 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL331310 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL123819 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL333111 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL333260 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL331305 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL122844 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL332588 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL122984 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL123080 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL122451 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL124599 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL122625 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL123604 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL122175 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2296511 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2296150 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL123458 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2296151 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL122747 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL123003 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL122991 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL340821 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL123930 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL123537 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL123174 | — | IC50 | = | 1900.0 | nM | 5.72 |