Assay Detail
Binding
CHEMBL1027672
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Inhibition of human nNOS by hemoglobin capture assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.55 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59925 | — | — | 1 | 7.00 |
| CHEMBL446971 | — | — | 1 | 6.22 |
| CHEMBL485160 | — | — | 1 | 6.16 |
| CHEMBL484826 | — | — | 1 | 5.52 |
| CHEMBL483973 | — | — | 1 | 5.40 |
| CHEMBL520645 | — | — | 1 | 5.38 |
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | 5.36 |
| CHEMBL484825 | — | — | 1 | 5.18 |
| CHEMBL21619 | 2-AMINOPYRIDINE | — | 1 | 5.14 |
| CHEMBL450234 | — | — | 1 | 4.91 |
| CHEMBL483940 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59925 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL446971 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL485160 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL484826 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL483973 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL520645 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL227744 | NITROARGININE | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL484825 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL21619 | 2-AMINOPYRIDINE | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL450234 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL483940 | — | IC50 | = | 15300.0 | nM | 4.82 |