Assay Detail
Functional
CHEMBL1027679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.98 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509065 | CONOCURVONE | — | 1 | 7.70 |
| CHEMBL295292 | MICHELLAMINE A | — | 1 | 6.00 |
| CHEMBL452483 | GUTTIFERONE A | — | 1 | 5.10 |
| CHEMBL501906 | PELTATOL A | — | 1 | 5.10 |
| CHEMBL498737 | XYLOPINIC ACID | — | 1 | - |
| CHEMBL170518 | PROSTRATIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509065 | CONOCURVONE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL295292 | MICHELLAMINE A | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL452483 | GUTTIFERONE A | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL501906 | PELTATOL A | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL498737 | XYLOPINIC ACID | EC50 | <= | 900.0 | nM | - |
| CHEMBL170518 | PROSTRATIN | EC50 | <= | 132.0 | nM | - |