Assay Detail
Functional
CHEMBL1027714
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL4909) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 7.43 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559065 | — | — | 1 | 9.70 |
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 9.70 |
| CHEMBL563646 | EVATANEPAG | 2.0 | 1 | 9.52 |
| CHEMBL541517 | — | — | 1 | 8.96 |
| CHEMBL541516 | — | — | 1 | 8.64 |
| CHEMBL549870 | — | — | 1 | 7.46 |
| CHEMBL562411 | — | — | 1 | 7.36 |
| CHEMBL556333 | — | — | 1 | 7.32 |
| CHEMBL556416 | — | — | 1 | 7.24 |
| CHEMBL549461 | — | — | 1 | 7.03 |
| CHEMBL559760 | — | — | 1 | 6.99 |
| CHEMBL551951 | — | — | 1 | 6.87 |
| CHEMBL549869 | — | — | 1 | 6.69 |
| CHEMBL559561 | — | — | 1 | 6.39 |
| CHEMBL550619 | — | — | 1 | 6.38 |
| CHEMBL554823 | — | — | 1 | 6.37 |
| CHEMBL558671 | — | — | 1 | 6.34 |
| CHEMBL559820 | — | — | 1 | 6.23 |
| CHEMBL562291 | — | — | 1 | 6.05 |
| CHEMBL559955 | — | — | 1 | - |
| CHEMBL549663 | — | — | 1 | - |
| CHEMBL549530 | — | — | 1 | - |
| CHEMBL562825 | — | — | 1 | - |
| CHEMBL553468 | — | — | 1 | - |
| CHEMBL550015 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559065 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL548 | DINOPROSTONE | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL563646 | EVATANEPAG | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL541517 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL541516 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL549870 | — | EC50 | = | 34.4 | nM | 7.46 |
| CHEMBL562411 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL556333 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL556416 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL549461 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL559760 | — | EC50 | = | 102.7 | nM | 6.99 |
| CHEMBL551951 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL549869 | — | EC50 | = | 203.0 | nM | 6.69 |
| CHEMBL559561 | — | EC50 | = | 407.0 | nM | 6.39 |
| CHEMBL550619 | — | EC50 | = | 413.0 | nM | 6.38 |
| CHEMBL554823 | — | EC50 | = | 423.0 | nM | 6.37 |
| CHEMBL558671 | — | EC50 | = | 457.0 | nM | 6.34 |
| CHEMBL559820 | — | EC50 | = | 587.0 | nM | 6.23 |
| CHEMBL562291 | — | EC50 | = | 887.0 | nM | 6.05 |
| CHEMBL559955 | — | EC50 | - | — | - | |
| CHEMBL549663 | — | EC50 | - | — | - | |
| CHEMBL549530 | — | EC50 | - | — | - | |
| CHEMBL562825 | — | EC50 | - | — | - | |
| CHEMBL553468 | — | EC50 | - | — | - | |
| CHEMBL550015 | — | EC50 | - | — | - |