Compound Detail
CHEMBL563646
EVATANEPAG 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL563646 |
| Name | EVATANEPAG |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | WOHRHWDYFNWPNG-UHFFFAOYSA-N |
2
Targets
4
Activities
3
Assay Types
2
PK Parameters
14
Publications
3
Known Names
1
Indications
1
Mechanisms
Molecular Properties
468.6
MW (Da)
4.23
ALogP
5
HBA
1
HBD
96.8
PSA (Ų)
0.50
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Prostanoid EP2 receptor agonist | AGONIST | Prostaglandin E2 receptor EP2 subtype | ✓ | ✓ |
Indications
Tibial Fractures
Activity Summary
EC50 2 meas. best 9.52
IC50 1 meas. best 7.3
Ki 1 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP2 subtype CHEMBL4909 | EC50 | 9.52 | 9.52 | 0.3 | 1 |
| Prostaglandin E2 receptor EP2 subtype CHEMBL1881 | EC50 | 8.3 | 8.3 | 5.0 | 1 |
| Prostaglandin E2 receptor EP2 subtype CHEMBL1881 | Ki | 7.3 | 7.3 | 50.0 | 1 |
| Prostaglandin E2 receptor EP2 subtype CHEMBL4909 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 56.0 | mL.min-1.kg-1 | Rattus norvegicus |
| T1/2 | 0.33 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP2 subtype | EC50 | = | 0.3 | nM | 9.52 | Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as ... | 19250823 |
| Prostaglandin E2 receptor EP2 subtype | EC50 | = | 5.0 | nM | 8.3 | Agonist activity at EP2 receptor (unknown origin) by functional assay | 24279689 |
| Prostaglandin E2 receptor EP2 subtype | IC50 | = | 50.0 | nM | 7.3 | Inhibition of rat EP2 receptor expressed in HEK293 cells | 19250823 |
| Prostaglandin E2 receptor EP2 subtype | Ki | = | 50.0 | nM | 7.3 | Binding affinity to EP2 receptor (unknown origin) by competitive binding assay | 24279689 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19250823 | 10.1016/j.bmcl.2009.01.059 | Mus musculus | 9 |
| 24279689 | 10.1021/jm401431x | Unchecked | 5 |
| 19250823 | 10.1016/j.bmcl.2009.01.059 | Rattus norvegicus | 3 |
| 19250823 | 10.1016/j.bmcl.2009.01.059 | Prostaglandin E2 receptor EP2 subtype | 2 |
| 24279689 | 10.1021/jm401431x | Prostaglandin E2 receptor EP2 subtype | 2 |
| 24279689 | 10.1021/jm401431x | Prostacyclin receptor | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 19250823 | 10.1016/j.bmcl.2009.01.059 | Prostaglandin E2 receptor EP4 subtype | 1 |
| 24279689 | 10.1021/jm401431x | Prostaglandin E2 receptor EP1 subtype | 1 |
| 24279689 | 10.1021/jm401431x | Prostaglandin E2 receptor EP3 subtype | 1 |
| 24279689 | 10.1021/jm401431x | Prostaglandin E2 receptor EP4 subtype | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine