Assay Detail
Binding
CHEMBL3294249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at EP2 receptor (unknown origin) by functional assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Prostanoid receptor EP2 as a therapeutic target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.24 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3286796 | — | — | 1 | 8.74 |
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 8.68 |
| CHEMBL2107783 | TAPRENEPAG | 2.0 | 1 | 8.55 |
| CHEMBL64246 | — | — | 1 | 8.42 |
| CHEMBL563646 | EVATANEPAG | 2.0 | 1 | 8.30 |
| CHEMBL1628262 | — | — | 1 | 7.50 |
| CHEMBL271896 | BUTAPROST | 2.0 | 1 | 7.48 |
| CHEMBL1722929 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3286796 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL548 | DINOPROSTONE | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2107783 | TAPRENEPAG | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL64246 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL563646 | EVATANEPAG | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1628262 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL271896 | BUTAPROST | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1722929 | — | EC50 | - | — | - |