Assay Detail
Binding
CHEMBL3294240
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Binding affinity to EP2 receptor (unknown origin) by competitive binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Prostanoid receptor EP2 as a therapeutic target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.42 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3286796 | — | — | 1 | 8.77 |
| CHEMBL64246 | — | — | 1 | 8.48 |
| CHEMBL2107783 | TAPRENEPAG | 2.0 | 1 | 8.00 |
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 7.42 |
| CHEMBL563646 | EVATANEPAG | 2.0 | 1 | 7.30 |
| CHEMBL1628262 | — | — | 1 | 7.14 |
| CHEMBL1722929 | — | — | 1 | 6.62 |
| CHEMBL271896 | BUTAPROST | 2.0 | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3286796 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL64246 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL2107783 | TAPRENEPAG | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL548 | DINOPROSTONE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL563646 | EVATANEPAG | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1628262 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL1722929 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL271896 | BUTAPROST | Ki | = | 2400.0 | nM | 5.62 |