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Assay Detail

CHEMBL1027885

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human WS1 cells after 48 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type WS1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins.
Gauthier C, Legault J, Lavoie S, Rondeau S, Tremblay S, Pichette A.
J Nat Prod (2009) 72 : 72 -81
PubMed 19115839 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.02 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL509430 1 5.89
CHEMBL23236 BETULIN 1 5.44
CHEMBL500006 1 5.35
CHEMBL509927 1 5.31
CHEMBL444506 1 5.28
CHEMBL509798 1 5.05
CHEMBL269277 BETULINIC ACID 1.0 1 4.92
CHEMBL507049 1 4.70
CHEMBL44657 ETOPOSIDE 4.0 1 4.47
CHEMBL453268 1 4.46
CHEMBL503523 1 4.30
CHEMBL553343 1 -
CHEMBL501076 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL509430 IC50 = 1300.0 nM 5.89
CHEMBL23236 BETULIN IC50 = 3600.0 nM 5.44
CHEMBL500006 IC50 = 4500.0 nM 5.35
CHEMBL509927 IC50 = 4900.0 nM 5.31
CHEMBL444506 IC50 = 5300.0 nM 5.28
CHEMBL509798 IC50 = 9000.0 nM 5.05
CHEMBL269277 BETULINIC ACID IC50 = 12000.0 nM 4.92
CHEMBL507049 IC50 = 20000.0 nM 4.70
CHEMBL44657 ETOPOSIDE IC50 = 34000.0 nM 4.47
CHEMBL453268 IC50 = 35000.0 nM 4.46
CHEMBL503523 IC50 = 50000.0 nM 4.30
CHEMBL553343 IC50 > 100000.0 nM -
CHEMBL501076 IC50 > 100000.0 nM -