Assay Detail
Binding
CHEMBL1028053
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human FGFR1 expressed in insect cells by HTRF method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.34 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480356 | — | — | 1 | 7.00 |
| CHEMBL231526 | — | — | 1 | 6.28 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480356 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL231526 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL274654 | ORANTINIB | IC50 | = | 1810.0 | nM | 5.74 |