Assay Detail
Binding
CHEMBL1028055
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Inhibition of PDGFRbeta
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.94 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480356 | — | — | 1 | 7.40 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | 7.30 |
| CHEMBL231526 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480356 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL274654 | ORANTINIB | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL231526 | — | IC50 | = | 780.0 | nM | 6.11 |