Assay Detail
Binding
CHEMBL1028093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AKT2
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.98 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523859 | — | — | 1 | 8.40 |
| CHEMBL522351 | — | — | 1 | 8.30 |
| CHEMBL494060 | — | — | 1 | 8.22 |
| CHEMBL1794065 | GSK-554170A | — | 1 | 8.10 |
| CHEMBL1794066 | GSK-619487A | — | 1 | 8.10 |
| CHEMBL493269 | — | — | 1 | 8.05 |
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 7.89 |
| CHEMBL494088 | — | — | 1 | 7.89 |
| CHEMBL453510 | — | — | 1 | 7.70 |
| CHEMBL521823 | — | — | 1 | 6.69 |
| CHEMBL188434 | — | — | 1 | 6.13 |
| CHEMBL493911 | — | — | 1 | 6.00 |
| CHEMBL523695 | — | — | 1 | 5.63 |
| CHEMBL493066 | — | — | 1 | 5.60 |
| CHEMBL494662 | — | — | 1 | 5.59 |
| CHEMBL506153 | GW876790X | — | 1 | 5.40 |
| CHEMBL493067 | — | — | 1 | 5.00 |
| CHEMBL521642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523859 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL522351 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL494060 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1794065 | GSK-554170A | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1794066 | GSK-619487A | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL493269 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL494089 | GSK-690693 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL494088 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL453510 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL521823 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL188434 | — | IC50 | = | 741.0 | nM | 6.13 |
| CHEMBL493911 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL523695 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL493066 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL494662 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL506153 | GW876790X | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL493067 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL521642 | — | IC50 | - | — | - |