Compound Detail
CHEMBL506153
GW876790X Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL506153 |
| Name | GW876790X |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RIIYKHQJSKRYKG-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
330.4
MW (Da)
0.03
ALogP
9
HBA
3
HBD
136.8
PSA (Ų)
0.54
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rho-associated protein kinase 1 CHEMBL3231 | IC50 | 8.3 | 8.3 | 5.0 | 1 |
| Ribosomal protein S6 kinase alpha-5 CHEMBL4237 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 6.9 | 6.9 | 126.0 | 1 |
| RAC-gamma serine/threonine-protein kinase CHEMBL4816 | IC50 | 5.85 | 5.85 | 1410.0 | 1 |
| RAC-beta serine/threonine-protein kinase CHEMBL2431 | IC50 | 5.4 | 5.4 | 3980.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rho-associated protein kinase 1 | IC50 | = | 5.0 | nM | 8.3 | Inhibition of human recombinant ROCK1 expressed in Sf9 cells | 18800763 |
| Ribosomal protein S6 kinase alpha-5 | IC50 | = | 15.0 | nM | 7.82 | Inhibition of MSK1 | 18800763 |
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 126.0 | nM | 6.9 | Inhibition of human AKT1 | 18800763 |
| RAC-gamma serine/threonine-protein kinase | IC50 | = | 1410.0 | nM | 5.85 | Inhibition of human AKT3 | 18800763 |
| RAC-beta serine/threonine-protein kinase | IC50 | = | 3980.0 | nM | 5.4 | Inhibition of human AKT2 | 18800763 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 14 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 10 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 8 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 8 |
| - | 10.6019/CHEMBL1961873 | Proto-oncogene tyrosine-protein kinase receptor Ret | 6 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lyn | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase B-raf | 4 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C beta type | 4 |
| - | 10.6019/CHEMBL1961873 | Receptor-type tyrosine-protein kinase FLT3 | 4 |
| - | 10.6019/CHEMBL1961873 | Cyclin-dependent kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Leucine-rich repeat serine/threonine-protein kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Insulin-like growth factor 1 receptor | 2 |
| - | 10.6019/CHEMBL1961873 | Insulin receptor | 2 |
| - | 10.6019/CHEMBL1961873 | Insulin receptor-related protein | 2 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ITK/TSK | 2 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase JAK1 | 2 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase JAK2 | 2 |
| - | 10.6019/CHEMBL1961873 | Macrophage colony-stimulating factor 1 receptor | 2 |
| - | 10.6019/CHEMBL1961873 | Vascular endothelial growth factor receptor 3 | 2 |
| - | 10.6019/CHEMBL1961873 | Leukocyte tyrosine kinase receptor | 2 |
Data from ChEMBL 36 via Core Engine