Rho-associated protein kinase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q13464. Use UniProt Q13464 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q13464 as the stable identity anchor, then attach disease evidence before program review.
Rho-associated protein kinase 1
Review this target as Rho-associated protein kinase 1, mapped to UniProt Q13464. Sequence length is 1354 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Rho-associated protein kinase 1 as ChEMBL target CHEMBL3231, mapped to UniProt Q13464. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Rho-associated protein kinase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q13464 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Rho-associated protein kinase 1 |
| UniProt Accession | Q13464 |
| Component Type | Protein |
| Sequence Length | 1354 aa |
Rho-associated protein kinase 1
Review this target as Rho-associated protein kinase 1, mapped to UniProt Q13464. Sequence length is 1354 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4753043 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL5901861 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL4107027 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL3902471 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL388978 | 9.55 | Kd | 0.28 | Preclinical |
| CHEMBL3961538 | 9.41 | IC50 | 0.39 | Preclinical |
| CHEMBL5987641 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL5739910 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL3949136 | 9.37 | IC50 | 0.43 | Preclinical |
| CHEMBL388978 | 9.35 | IC50 | 0.444 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 492 | 1,945 | 6.6 |
| assay format | 57 | 249 | 6.5 |
| cell-based format | 54 | 124 | 6.7 |
| subcellular format | 14 | 18 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 491 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 9 | 7.2 |