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Evidence Snapshot

Rho-associated protein kinase 1

CHEMBL3231 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:13:35Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3231
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Rho-associated protein kinase 1 as ChEMBL target CHEMBL3231, mapped to UniProt Q13464. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Rho-associated protein kinase 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3231
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q13464
Rho-associated protein kinase 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Rho-associated protein kinase 1 matters

As of 2026-09-13

Rho-associated protein kinase 1 is reviewed as Rho-associated protein kinase 1 (UniProt Q13464); the current evidence base includes 18 approved drugs, 5370 compounds, and 620 assays, with lead potency reaching pChEMBL 9.7.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 18 approved drugs, 5370 compounds, and 620 assays for this target. The dominant activity type is IC50. CHEMBL4753043 is the current potency anchor at pChEMBL 9.7.

Use CHEMBL4753043 as the tractability anchor when discussing potency (pChEMBL 9.7).

Activity source · ChEMBL 36 via Core Engine
18 approved pChEMBL 9.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Rho-associated protein kinase 1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q13464, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

5370
Total Compounds
620
Total Assays
18
Approved Drugs
IC50: 3207.0, KI: 1463.0, EC50: 25.0, KD: 346.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4753043
 9.7 Ki —
No preferred name
CHEMBL5901861
 9.7 IC50 —
No preferred name
CHEMBL4107027
 9.7 IC50 —
No preferred name
CHEMBL3902471
 9.6 IC50 —
No preferred name
CHEMBL388978
 9.6 Kd —

Approved Drugs

Structure Compound First Approval
CAPIVASERTIB
CHEMBL2325741
 2023
BELUMOSUDIL
CHEMBL2005186
 2021
UPADACITINIB
CHEMBL3622821
 2019
NETARSUDIL
CHEMBL4594250
 2017
BARICITINIB
CHEMBL2105759
 2017
TOFACITINIB CITRATE
CHEMBL2103743
 2012
TOFACITINIB
CHEMBL221959
 2012
BOSUTINIB
CHEMBL288441
 2012
RUXOLITINIB
CHEMBL1789941
 2011
SUNITINIB
CHEMBL535
 2006
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:13:35Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3231