Assay Detail
Binding
CHEMBL1028091
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Inhibition of MSK1
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.77 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521823 | — | — | 1 | 9.00 |
| CHEMBL523695 | — | — | 1 | 8.52 |
| CHEMBL188434 | — | — | 1 | 8.10 |
| CHEMBL493067 | — | — | 1 | 7.96 |
| CHEMBL494662 | — | — | 1 | 7.89 |
| CHEMBL506153 | GW876790X | — | 1 | 7.82 |
| CHEMBL493911 | — | — | 1 | 7.68 |
| CHEMBL493066 | — | — | 1 | 7.33 |
| CHEMBL445180 | — | — | 1 | 6.79 |
| CHEMBL493250 | — | — | 1 | 6.00 |
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 5.10 |
| CHEMBL494088 | — | — | 1 | 5.00 |
| CHEMBL493874 | — | — | 1 | 4.80 |
| CHEMBL493269 | — | — | 1 | 4.80 |
| CHEMBL494060 | — | — | 1 | 4.70 |
| CHEMBL523523 | — | — | 1 | - |
| CHEMBL494882 | — | — | 1 | - |
| CHEMBL450487 | — | — | 1 | - |
| CHEMBL523057 | — | — | 1 | - |
| CHEMBL493875 | — | — | 1 | - |
| CHEMBL493251 | — | — | 1 | - |
| CHEMBL1794064 | GSK-561866B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521823 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL523695 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL188434 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL493067 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL494662 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL506153 | GW876790X | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL493911 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL493066 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL445180 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL493250 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL494089 | GSK-690693 | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL494088 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL493874 | — | IC50 | = | 15850.0 | nM | 4.80 |
| CHEMBL493269 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL494060 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL523523 | — | IC50 | - | — | - | |
| CHEMBL494882 | — | IC50 | - | — | - | |
| CHEMBL450487 | — | IC50 | - | — | - | |
| CHEMBL523057 | — | IC50 | - | — | - | |
| CHEMBL493875 | — | IC50 | - | — | - | |
| CHEMBL493251 | — | IC50 | - | — | - | |
| CHEMBL1794064 | GSK-561866B | IC50 | - | — | - |