Compound Detail
CHEMBL494882
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Basic Information
| ChEMBL ID | CHEMBL494882 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UBGKZPSSXPFLIM-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
367.4
MW (Da)
1.57
ALogP
9
HBA
2
HBD
130.9
PSA (Ų)
0.50
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 7.1 | 6.255 | 79.0 | 2 |
| Ribosomal protein S6 kinase alpha-1 CHEMBL2553 | IC50 | 6.6 | 6.6 | 251.0 | 1 |
| Rho-associated protein kinase 1 CHEMBL3231 | IC50 | 5.7 | 5.7 | 1995.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 79.0 | nM | 7.1 | Inhibition of human AKT1 | 18800763 |
| Ribosomal protein S6 kinase alpha-1 | IC50 | = | 251.0 | nM | 6.6 | Inhibition of RSK1 | 18800763 |
| Rho-associated protein kinase 1 | IC50 | = | 1995.0 | nM | 5.7 | Inhibition of human recombinant ROCK1 expressed in Sf9 cells | 18800763 |
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 3900.0 | nM | 5.41 | Inhibition of AKT-mediated GSK3-beta phosphorylation in human BT474 cells | 18800763 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18800763 | 10.1021/jm8004527 | RAC-alpha serine/threonine-protein kinase | 2 |
| 18800763 | 10.1021/jm8004527 | Ribosomal protein S6 kinase alpha-5 | 1 |
| 18800763 | 10.1021/jm8004527 | Rho-associated protein kinase 1 | 1 |
| 18800763 | 10.1021/jm8004527 | Ribosomal protein S6 kinase alpha-1 | 1 |
Data from ChEMBL 36 via Core Engine