Assay Detail
Binding
CHEMBL1028103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RSK1
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.51 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523523 | — | — | 1 | 9.00 |
| CHEMBL493875 | — | — | 1 | 8.22 |
| CHEMBL493251 | — | — | 1 | 7.89 |
| CHEMBL493250 | — | — | 1 | 7.36 |
| CHEMBL445180 | — | — | 1 | 7.15 |
| CHEMBL1794064 | GSK-561866B | — | 1 | 6.60 |
| CHEMBL494882 | — | — | 1 | 6.60 |
| CHEMBL522351 | — | — | 1 | 6.30 |
| CHEMBL453510 | — | — | 1 | 6.30 |
| CHEMBL493269 | — | — | 1 | 6.10 |
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 5.90 |
| CHEMBL493874 | — | — | 1 | 5.90 |
| CHEMBL523859 | — | — | 1 | 5.81 |
| CHEMBL521642 | — | — | 1 | 5.80 |
| CHEMBL494088 | — | — | 1 | 5.70 |
| CHEMBL1794065 | GSK-554170A | — | 1 | 5.60 |
| CHEMBL494060 | — | — | 1 | 5.60 |
| CHEMBL1794066 | GSK-619487A | — | 1 | 5.40 |
| CHEMBL523057 | — | — | 1 | - |
| CHEMBL450487 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523523 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL493875 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL493251 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL493250 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL445180 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1794064 | GSK-561866B | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL494882 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL522351 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL453510 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL493269 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL494089 | GSK-690693 | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL493874 | — | IC50 | = | 1259.0 | nM | 5.90 |
| CHEMBL523859 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL521642 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL494088 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL1794065 | GSK-554170A | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL494060 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL1794066 | GSK-619487A | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL523057 | — | IC50 | - | — | - | |
| CHEMBL450487 | — | IC50 | - | — | - |