Assay Detail
Binding
CHEMBL1028094
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Inhibition of human AKT3
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.51 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 8.05 |
| CHEMBL494060 | — | — | 1 | 7.80 |
| CHEMBL1794065 | GSK-554170A | — | 1 | 7.40 |
| CHEMBL493269 | — | — | 1 | 7.16 |
| CHEMBL521823 | — | — | 1 | 6.42 |
| CHEMBL493911 | — | — | 1 | 6.40 |
| CHEMBL188434 | — | — | 1 | 6.19 |
| CHEMBL523695 | — | — | 1 | 5.89 |
| CHEMBL506153 | GW876790X | — | 1 | 5.85 |
| CHEMBL493066 | — | — | 1 | 5.81 |
| CHEMBL494662 | — | — | 1 | 5.64 |
| CHEMBL493067 | — | — | 1 | 5.52 |
| CHEMBL453510 | — | — | 1 | - |
| CHEMBL523859 | — | — | 1 | - |
| CHEMBL494088 | — | — | 1 | - |
| CHEMBL1794066 | GSK-619487A | — | 1 | - |
| CHEMBL521642 | — | — | 1 | - |
| CHEMBL522351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494089 | GSK-690693 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL494060 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1794065 | GSK-554170A | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL493269 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL521823 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL493911 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL188434 | — | IC50 | = | 646.0 | nM | 6.19 |
| CHEMBL523695 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL506153 | GW876790X | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL493066 | — | IC50 | = | 1549.0 | nM | 5.81 |
| CHEMBL494662 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL493067 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL453510 | — | IC50 | - | — | - | |
| CHEMBL523859 | — | IC50 | - | — | - | |
| CHEMBL494088 | — | IC50 | - | — | - | |
| CHEMBL1794066 | GSK-619487A | IC50 | - | — | - | |
| CHEMBL521642 | — | IC50 | - | — | - | |
| CHEMBL522351 | — | IC50 | - | — | - |