Assay Detail
Functional
CHEMBL1028099
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Antiproliferative activity against human BT474 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.21 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 7.30 |
| CHEMBL494060 | — | — | 1 | 6.58 |
| CHEMBL523859 | — | — | 1 | 6.44 |
| CHEMBL1794065 | GSK-554170A | — | 1 | 6.42 |
| CHEMBL453510 | — | — | 1 | 6.38 |
| CHEMBL493269 | — | — | 1 | 6.16 |
| CHEMBL521642 | — | — | 1 | 6.12 |
| CHEMBL494088 | — | — | 1 | 5.99 |
| CHEMBL1794066 | GSK-619487A | — | 1 | 5.89 |
| CHEMBL522351 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494089 | GSK-690693 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL494060 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL523859 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1794065 | GSK-554170A | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL453510 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL493269 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL521642 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL494088 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1794066 | GSK-619487A | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL522351 | — | IC50 | = | 14200.0 | nM | 4.85 |