Assay Detail
Binding
CHEMBL1028365
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Inhibition of rat fetal brain CDK5 assessed as phosphorylated histone H1 levels by immuno-precipitation
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effects of natural flavones and flavonols on the kinase activity of Cdk5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 4.33 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293776 | HISPIDULIN | — | 1 | 4.72 |
| CHEMBL172350 | EUPAFOLIN | — | 1 | 4.40 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.20 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.18 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.15 |
| CHEMBL28 | APIGENIN | — | 1 | - |
| CHEMBL464108 | — | — | 1 | - |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | - |
| CHEMBL59220 | — | — | 1 | - |
| CHEMBL55415 | SCUTELLAREIN | — | 1 | - |
| CHEMBL465155 | PATULETIN | — | 1 | - |
| CHEMBL462898 | — | — | 1 | - |
| CHEMBL413552 | QUERCETAGETIN | — | 1 | - |
| CHEMBL455504 | 6-HYDROXYKAEMPFEROL | — | 1 | - |
| CHEMBL464107 | 6-HYDROXYLUTEOLIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293776 | HISPIDULIN | EC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL172350 | EUPAFOLIN | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL50 | QUERCETIN | EC50 | = | 63400.0 | nM | 4.20 |
| CHEMBL150 | KAEMPFEROL | EC50 | = | 66100.0 | nM | 4.18 |
| CHEMBL164 | MYRICETIN | EC50 | = | 71100.0 | nM | 4.15 |
| CHEMBL28 | APIGENIN | EC50 | > | 250000.0 | nM | - |
| CHEMBL464108 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL151 | LUTEOLIN | EC50 | > | 250000.0 | nM | - |
| CHEMBL59220 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL55415 | SCUTELLAREIN | EC50 | - | — | - | |
| CHEMBL465155 | PATULETIN | EC50 | - | — | - | |
| CHEMBL462898 | — | EC50 | - | — | - | |
| CHEMBL413552 | QUERCETAGETIN | EC50 | - | — | - | |
| CHEMBL455504 | 6-HYDROXYKAEMPFEROL | EC50 | - | — | - | |
| CHEMBL464107 | 6-HYDROXYLUTEOLIN | EC50 | - | — | - |