Compound Detail
CHEMBL464107
6-HYDROXYLUTEOLIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL464107 |
| Name | 6-HYDROXYLUTEOLIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VYAKIUWQLHRZGK-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
302.2
MW (Da)
1.99
ALogP
7
HBA
5
HBD
131.4
PSA (Ų)
0.43
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 CHEMBL2622 | IC50 | 6.69 | 6.69 | 204.2 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.94 | 4.94 | 11600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 | IC50 | = | 204.17 | nM | 6.69 | Inhibition of rat lens aldose reductase | 18585047 |
| Unchecked | IC50 | = | 11600.0 | nM | 4.94 | Inhibition of dephosphorylated glycogen phosphorylase | 21856048 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25524452 | 10.1021/np5004092 | Staphylococcus aureus | 4 |
| 15043421 | 10.1021/np034011s | Cyclin-dependent kinase 5 | 1 |
| 18585047 | 10.1016/j.bmc.2008.06.004 | Aldo-keto reductase family 1 member B1 | 1 |
| 21856048 | 10.1016/j.ejmech.2011.07.059 | Unchecked | 1 |
| - | 10.1007/s00044-011-9570-z | Avian myoblastosis virus polyprotein II | 1 |
Data from ChEMBL 36 via Core Engine