Assay Detail
ADMET
CHEMBL1028440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against HEK293 cells after 72 hrs by MTT conversion assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative triterpene saponins from Entada africana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.42 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | 4.0 | 1 | 8.15 |
| CHEMBL508996 | — | — | 1 | 6.60 |
| CHEMBL507309 | — | — | 1 | 6.57 |
| CHEMBL503852 | — | — | 1 | 6.44 |
| CHEMBL527074 | — | — | 1 | 6.25 |
| CHEMBL510401 | — | — | 1 | 5.55 |
| CHEMBL518082 | — | — | 1 | 5.41 |
| CHEMBL508662 | — | — | 1 | - |
| CHEMBL504806 | — | — | 1 | - |
| CHEMBL499449 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL508996 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL507309 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL503852 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL527074 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL510401 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL518082 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL508662 | — | IC50 | - | — | - | |
| CHEMBL504806 | — | IC50 | - | — | - | |
| CHEMBL499449 | — | IC50 | - | — | - |