Assay Detail
Functional
CHEMBL1029757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.68 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.96 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.96 |
| CHEMBL182739 | — | — | 1 | 8.26 |
| CHEMBL474864 | — | — | 1 | 6.73 |
| CHEMBL444562 | — | — | 1 | 6.62 |
| CHEMBL474256 | — | — | 1 | 6.58 |
| CHEMBL499940 | — | — | 1 | 6.52 |
| CHEMBL519303 | — | — | 1 | 6.50 |
| CHEMBL473857 | — | — | 1 | 6.36 |
| CHEMBL444693 | — | — | 1 | 6.36 |
| CHEMBL482340 | — | — | 1 | 6.25 |
| CHEMBL514635 | — | — | 1 | 6.22 |
| CHEMBL502039 | — | — | 1 | 6.19 |
| CHEMBL475874 | — | — | 1 | 6.15 |
| CHEMBL506441 | — | — | 1 | 6.12 |
| CHEMBL454710 | — | — | 1 | 6.08 |
| CHEMBL475873 | — | — | 1 | 5.77 |
| CHEMBL502241 | — | — | 1 | 5.62 |
| CHEMBL321473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL182739 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL474864 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL444562 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL474256 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL499940 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL519303 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL473857 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL444693 | — | IC50 | = | 438.0 | nM | 6.36 |
| CHEMBL482340 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL514635 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL502039 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL475874 | — | IC50 | = | 709.0 | nM | 6.15 |
| CHEMBL506441 | — | IC50 | = | 752.0 | nM | 6.12 |
| CHEMBL454710 | — | IC50 | = | 841.0 | nM | 6.08 |
| CHEMBL475873 | — | IC50 | = | 1712.0 | nM | 5.77 |
| CHEMBL502241 | — | IC50 | = | 2403.0 | nM | 5.62 |
| CHEMBL321473 | — | IC50 | - | — | - |