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Assay Detail

CHEMBL1029934

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Binding
Inhibition of Huntingtin protein aggregation by cell based assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Huntingtin (CHEMBL5514)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.
Rinderspacher A, Cremona ML, Liu Y, Deng SX, Xie Y, Gong G, Aulner N, Többen U, Myers K, Chung C, Andersen M, Vidović D, Schürer S, Brandén L, Yamamoto A, Landry DW.
Bioorg Med Chem Lett (2009) 19 : 1715 -1717
PubMed 19243939 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 5.50 6.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL493153 1 6.15
CHEMBL493327 1 5.97
CHEMBL500972 1 5.96
CHEMBL495005 1 5.88
CHEMBL494838 1 5.66
CHEMBL509988 1 5.56
CHEMBL149800 1 5.46
CHEMBL445226 1 5.44
CHEMBL494130 1 5.35
CHEMBL444229 1 5.28
CHEMBL494325 1 5.27
CHEMBL494326 1 5.21
CHEMBL493348 1 5.20
CHEMBL449571 1 5.09
CHEMBL153483 1 4.98
CHEMBL451222 1 -
CHEMBL493324 1 -
CHEMBL489053 1 -
CHEMBL506969 1 -
CHEMBL442675 1 -
CHEMBL493349 1 -
CHEMBL493350 1 -
CHEMBL493325 1 -
CHEMBL153733 1 -
CHEMBL450176 1 -
CHEMBL493308 1 -
CHEMBL522502 1 -
CHEMBL493309 1 -
CHEMBL494129 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL493153 IC50 = 710.0 nM 6.15
CHEMBL493327 IC50 = 1070.0 nM 5.97
CHEMBL500972 IC50 = 1110.0 nM 5.96
CHEMBL495005 IC50 = 1310.0 nM 5.88
CHEMBL494838 IC50 = 2210.0 nM 5.66
CHEMBL509988 IC50 = 2740.0 nM 5.56
CHEMBL149800 IC50 = 3440.0 nM 5.46
CHEMBL445226 IC50 = 3630.0 nM 5.44
CHEMBL494130 IC50 = 4480.0 nM 5.35
CHEMBL444229 IC50 = 5260.0 nM 5.28
CHEMBL494325 IC50 = 5360.0 nM 5.27
CHEMBL494326 IC50 = 6130.0 nM 5.21
CHEMBL493348 IC50 = 6380.0 nM 5.20
CHEMBL449571 IC50 = 8130.0 nM 5.09
CHEMBL153483 IC50 = 10500.0 nM 4.98
CHEMBL451222 IC50 > 10000.0 nM -
CHEMBL493324 IC50 > 10000.0 nM -
CHEMBL489053 IC50 > 10000.0 nM -
CHEMBL506969 IC50 > 10000.0 nM -
CHEMBL442675 IC50 > 10000.0 nM -
CHEMBL493349 IC50 > 10000.0 nM -
CHEMBL493350 IC50 > 15800.0 nM -
CHEMBL493325 IC50 - -
CHEMBL153733 IC50 - -
CHEMBL450176 IC50 - -
CHEMBL493308 IC50 - -
CHEMBL522502 IC50 - -
CHEMBL493309 IC50 - -
CHEMBL494129 IC50 - -