Assay Detail
Binding
CHEMBL1030286
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Inhibition of Serratia marcescens chitinase B
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Serratia marcescens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.50 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555042 | — | — | 1 | 6.64 |
| CHEMBL538640 | — | — | 1 | 5.89 |
| CHEMBL541740 | — | — | 1 | 5.72 |
| CHEMBL549731 | — | — | 1 | 5.35 |
| CHEMBL553459 | — | — | 1 | 5.21 |
| CHEMBL197199 | ARGIFIN | — | 1 | 5.19 |
| CHEMBL557497 | — | — | 1 | 5.00 |
| CHEMBL538641 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555042 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL538640 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL541740 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL549731 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL553459 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL197199 | ARGIFIN | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL557497 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL538641 | — | IC50 | = | 9900.0 | nM | 5.00 |