Assay Detail
Binding
CHEMBL1030560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT1 after 55 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.30 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485214 | — | — | 1 | 5.85 |
| CHEMBL485213 | — | — | 1 | 5.19 |
| CHEMBL521179 | SR-3677 | — | 1 | 5.12 |
| CHEMBL485215 | — | — | 1 | 5.05 |
| CHEMBL510515 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485214 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL485213 | — | IC50 | = | 6436.0 | nM | 5.19 |
| CHEMBL521179 | SR-3677 | IC50 | = | 7491.0 | nM | 5.12 |
| CHEMBL485215 | — | IC50 | = | 8819.0 | nM | 5.05 |
| CHEMBL510515 | — | IC50 | > | 20000.0 | nM | - |