Assay Detail
Binding
CHEMBL1030589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ENT1
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Equilibrative nucleoside transporter 1 (CHEMBL1997) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
CoMFA and CoMSIA 3D-QSAR studies on S(6)-(4-nitrobenzyl)mercaptopurine riboside (NBMPR) analogs as inhibitors of human equilibrative nucleoside transporter 1 (hENT1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 7.60 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418509 | NITROBENZYLMERCAPTOPURINE RIBONUCLEOSIDE | — | 1 | 9.15 |
| CHEMBL61773 | — | — | 1 | 8.75 |
| CHEMBL512162 | — | — | 1 | 8.42 |
| CHEMBL61741 | — | — | 1 | 8.36 |
| CHEMBL61915 | — | — | 1 | 8.34 |
| CHEMBL432688 | — | — | 1 | 8.15 |
| CHEMBL418496 | — | — | 1 | 8.04 |
| CHEMBL430946 | — | — | 1 | 7.94 |
| CHEMBL58072 | — | — | 1 | 7.90 |
| CHEMBL517945 | — | — | 1 | 7.89 |
| CHEMBL473492 | — | — | 1 | 7.86 |
| CHEMBL61387 | — | — | 1 | 7.83 |
| CHEMBL294755 | — | — | 1 | 7.82 |
| CHEMBL59168 | — | — | 1 | 7.79 |
| CHEMBL464810 | — | — | 1 | 7.74 |
| CHEMBL59195 | — | — | 1 | 7.72 |
| CHEMBL516202 | — | — | 1 | 7.71 |
| CHEMBL60662 | 6-BENZYLTHIOINOSINE | — | 1 | 7.70 |
| CHEMBL475104 | — | — | 1 | 7.68 |
| CHEMBL60735 | — | — | 1 | 7.62 |
| CHEMBL61524 | — | — | 1 | 7.46 |
| CHEMBL471062 | — | — | 1 | 7.44 |
| CHEMBL471061 | — | — | 1 | 7.41 |
| CHEMBL293957 | — | — | 1 | 7.33 |
| CHEMBL540448 | — | — | 1 | 7.17 |
| CHEMBL59683 | — | — | 1 | 7.06 |
| CHEMBL470024 | — | — | 1 | 6.94 |
| CHEMBL292374 | — | — | 1 | 6.93 |
| CHEMBL475103 | — | — | 1 | 6.82 |
| CHEMBL60779 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418509 | NITROBENZYLMERCAPTOPURINE RIBONUCLEOSIDE | Ki | = | 0.7079 | nM | 9.15 |
| CHEMBL61773 | — | Ki | = | 1.778 | nM | 8.75 |
| CHEMBL512162 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL61741 | — | Ki | = | 4.365 | nM | 8.36 |
| CHEMBL61915 | — | Ki | = | 4.571 | nM | 8.34 |
| CHEMBL432688 | — | Ki | = | 7.079 | nM | 8.15 |
| CHEMBL418496 | — | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL430946 | — | Ki | = | 11.48 | nM | 7.94 |
| CHEMBL58072 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL517945 | — | Ki | = | 12.88 | nM | 7.89 |
| CHEMBL473492 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL61387 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL294755 | — | Ki | = | 15.14 | nM | 7.82 |
| CHEMBL59168 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL464810 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL59195 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL516202 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL60662 | 6-BENZYLTHIOINOSINE | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL475104 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL60735 | — | Ki | = | 23.99 | nM | 7.62 |
| CHEMBL61524 | — | Ki | = | 34.67 | nM | 7.46 |
| CHEMBL471062 | — | Ki | = | 36.31 | nM | 7.44 |
| CHEMBL471061 | — | Ki | = | 38.9 | nM | 7.41 |
| CHEMBL293957 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL540448 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL59683 | — | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL470024 | — | Ki | = | 114.82 | nM | 6.94 |
| CHEMBL292374 | — | Ki | = | 117.49 | nM | 6.93 |
| CHEMBL475103 | — | Ki | = | 151.36 | nM | 6.82 |
| CHEMBL60779 | — | Ki | = | 1905.46 | nM | 5.72 |
| CHEMBL292248 | — | Ki | = | 10000.0 | nM | 5.00 |