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Target Snapshot

CHEMBL1997 Target Snapshot

Equilibrative nucleoside transporter 1 · SINGLE PROTEIN · Homo sapiens

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1,450Compounds
46Assays
6Approved Drugs
474.0Activities
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As of 2026-09-13

Equilibrative nucleoside transporter 1 shows approved-linked disease relevance led by coronary artery disease. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q99808. Start with coronary artery disease, then reuse UniProt Q99808 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with coronary artery disease, then reuse UniProt Q99808 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
coronary artery disease

Equilibrative nucleoside transporter 1 shows approved-linked disease relevance led by coronary artery disease. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with coronary artery disease because it currently carries approved-linked support. Linked drugs include DIPYRIDAMOLE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Equilibrative nucleoside transporter 1 as ChEMBL target CHEMBL1997, mapped to UniProt Q99808. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Equilibrative nucleoside transporter 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1997
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q99808
Equilibrative nucleoside transporter 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Equilibrative nucleoside transporter 1 is the right protein anchor across sources, using UniProt Q99808 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why coronary artery disease is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameEquilibrative nucleoside transporter 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ99808
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEquilibrative nucleoside transporter 1
UniProt AccessionQ99808
Component TypeProtein
Sequence Length456 aa

Equilibrative nucleoside transporter 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Equilibrative nucleoside transporter 1, mapped to UniProt Q99808. Sequence length is 456 aa.

Mapped IDQ99808
Review nameEquilibrative nucleoside transporter 1
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Equilibrative nucleoside transporter 1 shows approved-linked disease relevance led by coronary artery disease. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
coronary artery disease
1 linked drug · 1 direct · 1 efficacy
Linked drugDIPYRIDAMOLE
Approved-linked Approved
Recurrent thrombophlebitis
1 linked drug · 1 direct · 1 efficacy
Linked drugDIPYRIDAMOLE
Approved-linked Approved
stroke
1 linked drug · 1 direct · 1 efficacy
Linked drugDIPYRIDAMOLE
Late clinical Phase III
angina pectoris
1 linked drug · 1 direct · 1 efficacy
Linked drugDIPYRIDAMOLE
Late clinical Phase III
cardiovascular disease
1 linked drug · 1 direct · 1 efficacy
Linked drugDIPYRIDAMOLE
Late clinical Phase III
COVID-19
1 linked drug · 1 direct · 1 efficacy
Linked drugDIPYRIDAMOLE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with coronary artery disease because it currently carries approved-linked support. Linked drugs include DIPYRIDAMOLE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasecoronary artery disease
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

6
Approved
2
Phase III
7
Phase II
Assay Mix

Activity Type Distribution

IC50233.0
KI233.0
EC501.0
KD7.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL571939 10.74 Ki 0.018 Preclinical
CHEMBL569223 10.19 Ki 0.064 Preclinical
CHEMBL126075 10.0 IC50 0.1 Clinical
CHEMBL569224 9.59 Kd 0.26 Preclinical
CHEMBL1628717 9.55 Ki 0.28 Clinical
CHEMBL418509 9.52 IC50 0.3 Preclinical
CHEMBL418509 9.37 Ki 0.43 Preclinical
CHEMBL260570 9.35 Ki 0.45 Preclinical
CHEMBL243304 9.31 Ki 0.49 Preclinical
CHEMBL610234 9.19 Ki 0.64 Preclinical
Distribution

pChEMBL Value Distribution

24
5.0
29
5.5
40
6.0
66
6.5
32
7.0
47
7.5
29
8.0
9
8.5
20
9.0
3
9.5
pChEMBL
Approved Drugs

Approved Drugs

GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DIPYRIDAMOLE
CHEMBL932
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

46
Total Assays
291
Tested Compounds
3
Assay Types
Binding — 35 assays, 291 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 20 88 7.2
single protein format 11 144 6.4
assay format 2 38 6.5
cell membrane format 2 21 7.7
ADME — 9 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 4 6.5
single protein format 2 0 —
assay format 1 3 4.7
Functional — 2 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 5 7.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine