Assay Detail
Binding
CHEMBL1030715
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Binding affinity to Escherichia coli K12 KAS 3 expressed in Escherichia coli BL21 by fluorescence quenching analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli K-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Beta-ketoacyl-[acyl-carrier-protein] synthase III (CHEMBL4914) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.81 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458164 | — | — | 1 | 7.70 |
| CHEMBL459369 | — | — | 1 | 5.91 |
| CHEMBL399043 | THIOLACTOMYCIN | — | 1 | - |
| CHEMBL459370 | — | — | 1 | - |
| CHEMBL513094 | — | — | 1 | - |
| CHEMBL511704 | — | — | 1 | - |
| CHEMBL456426 | — | — | 1 | - |
| CHEMBL458163 | — | — | 1 | - |
| CHEMBL512737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458164 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL459369 | — | Kd | = | 1220.0 | nM | 5.91 |
| CHEMBL399043 | THIOLACTOMYCIN | Kd | = | 121000.0 | nM | - |
| CHEMBL459370 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL513094 | — | Kd | = | 141000.0 | nM | - |
| CHEMBL511704 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL456426 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL458163 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL512737 | — | Kd | > | 1000000.0 | nM | - |