Assay Detail
Functional
CHEMBL1031066
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Cytotoxicity against human H1299 cells assessed as cell viability after 72 hrs by ATP-LITE assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 5.39 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541496 | — | — | 1 | 6.44 |
| CHEMBL552735 | — | — | 1 | 6.24 |
| CHEMBL564558 | — | — | 1 | 5.92 |
| CHEMBL541005 | — | — | 1 | 5.89 |
| CHEMBL550422 | — | — | 1 | 5.75 |
| CHEMBL539480 | — | — | 1 | 5.51 |
| CHEMBL538616 | — | — | 1 | 5.50 |
| CHEMBL539481 | — | — | 1 | 5.50 |
| CHEMBL551288 | APOGOSSYPOL | — | 1 | 5.47 |
| CHEMBL541003 | — | — | 1 | 5.44 |
| CHEMBL552287 | — | — | 1 | 5.44 |
| CHEMBL554545 | — | — | 1 | 5.44 |
| CHEMBL541004 | — | — | 1 | 5.32 |
| CHEMBL554132 | — | — | 1 | 5.30 |
| CHEMBL554133 | — | — | 1 | 5.28 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 5.22 |
| CHEMBL541427 | — | — | 1 | 5.15 |
| CHEMBL553474 | — | — | 1 | 5.11 |
| CHEMBL554104 | — | — | 1 | 5.10 |
| CHEMBL555284 | — | — | 1 | 5.10 |
| CHEMBL561820 | — | — | 1 | 4.96 |
| CHEMBL561351 | — | — | 1 | 4.87 |
| CHEMBL540424 | — | — | 1 | 4.77 |
| CHEMBL556334 | — | — | 1 | 4.54 |
| CHEMBL540425 | — | — | 1 | - |
| CHEMBL554601 | — | — | 1 | - |
| CHEMBL557761 | — | — | 1 | - |
| CHEMBL554546 | — | — | 1 | - |
| CHEMBL560035 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541496 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL552735 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL564558 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL541005 | — | EC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL550422 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL539480 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL538616 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL539481 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL551288 | APOGOSSYPOL | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL541003 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL552287 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL554545 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL541004 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL554132 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL554133 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL51483 | GOSSYPOL | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL541427 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL553474 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL554104 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL555284 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL561820 | — | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL561351 | — | EC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL540424 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL556334 | — | EC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL540425 | — | EC50 | - | — | - | |
| CHEMBL554601 | — | EC50 | - | — | - | |
| CHEMBL557761 | — | EC50 | - | — | - | |
| CHEMBL554546 | — | EC50 | - | — | - | |
| CHEMBL560035 | — | EC50 | > | 30000.0 | nM | - |