Assay Detail
Binding
CHEMBL1031183
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Inhibition of [3H]NMS binding to muscarinic receptor in mouse N4TG1 neuroblastoma cells
27
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3D-QSAR studies of 2,2-diphenylpropionates to aid discovery of novel potent muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.52 | 9.00 |
| pKi | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562759 | — | — | 1 | 9.00 |
| CHEMBL549553 | — | — | 1 | 8.80 |
| CHEMBL541169 | — | — | 1 | 8.70 |
| CHEMBL607172 | — | — | 1 | 8.40 |
| CHEMBL517712 | ATROPINE | 4.0 | 2 | 8.40 |
| CHEMBL110339 | — | — | 1 | 8.30 |
| CHEMBL564476 | — | — | 1 | 8.30 |
| CHEMBL26505 | APROFENE | 2.0 | 1 | 8.20 |
| CHEMBL560051 | — | — | 1 | 8.20 |
| CHEMBL564911 | — | — | 1 | 8.20 |
| CHEMBL563476 | — | — | 1 | 8.20 |
| CHEMBL560052 | — | — | 1 | 8.00 |
| CHEMBL540472 | — | — | 1 | 7.80 |
| CHEMBL559656 | — | — | 1 | 7.80 |
| CHEMBL557294 | — | — | 1 | 7.70 |
| CHEMBL549828 | — | — | 1 | 7.70 |
| CHEMBL560571 | — | — | 1 | 7.10 |
| CHEMBL560649 | — | — | 1 | 7.10 |
| CHEMBL564636 | — | — | 1 | 6.90 |
| CHEMBL552251 | — | — | 1 | 6.80 |
| CHEMBL550233 | — | — | 1 | 6.80 |
| CHEMBL564133 | — | — | 1 | 6.30 |
| CHEMBL541975 | — | — | 1 | 5.50 |
| CHEMBL551585 | — | — | 1 | 5.30 |
| CHEMBL569603 | — | — | 1 | 4.50 |
| CHEMBL555069 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562759 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL549553 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL541169 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL607172 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL517712 | ATROPINE | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL110339 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL564476 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL26505 | APROFENE | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL560051 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL564911 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL563476 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL560052 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL540472 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL559656 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL557294 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL549828 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL560571 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL560649 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL564636 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL552251 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL550233 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL564133 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL541975 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL551585 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL569603 | — | Ki | = | 31622.78 | nM | 4.50 |
| CHEMBL555069 | — | Ki | < | 467735.14 | nM | - |
| CHEMBL517712 | ATROPINE | pKi | - | — | - |